Registered Charity No. 1044906 01691 404661

ORTHOPAEDIC
INSTITUTE RESEARCH

Rheumatology and Metabolic Medicine

Members of the Research Team:
Dr Oksana Kehoe (Lead), Miss Rebecca Morgan and Miss Mairead Hyland

Clinical Support:
Dr Roshan Amarasena (Lead), Dr Rob Butler and Dr Ayman Askari

Our team has continued to be active this year carrying out basic science work into understanding mechanisms of rheumatoid arthritis (RA) progression and possible treatments.

We have been publishing our findings in Arthritis Research & Therapy and eCM Periodical. We have presented our work at several national and international meetings such as the Annual TCES meeting, June 2018, Keele University; the Gordon Research Conference on Proteoglycans, July 2018, USA; the 2nd Vinmec Conference on Cell&Gene Therapy, October 2018, Hanoi, Vietnam; the Mercia Stem Cell Alliance Eighth Annual Scientific Meeting, December 2018, Birmingham; the UK Society for Extracellular Vesicles Annual Forum, December 2018, Sheffield; the International Society for Extracellular Vesicles Annual Meeting, April 2019, Japan; the Annual Research day at the RJAH, April 2019 and TERMIS EU 2019, May 2019, Rhodes, Greece.

The projects which we are currently working are explained below.

 

Mairead Hyland (1) and Oksana Kehoe (2)  presenting their work at the conferences.

 

Rheumatology & Metabolic Medicine Projects

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Disease Severity in Inflammatory Arthritis

Alasdair Kay, Rebecca Morgan, Mairead Hyland, Andrei Stefan, Oksana Kehoe

Funding was provided by the Orthopaedic Institute Ltd, Oswestry Rheumatology Association and RJAH Hospital Charity

The in vitro effect of syndecan-3 gene knockout on bone marrow derived mesenchymal stem cells’ properties (Preclinical studies)

Andrei Stefan, Alasdair Kay, Nick Forsyth, Fiona Jones*, Dada Pisconti*, Oksana Kehoe
*University of Liverpool

Funded by Orthopaedic Institute, Keele University School of Medicine and Oswestry Rheumatology Association

Uncovering the role of proteoglycans in exosome biogenesis for improved regenerative medicine therapies

Rebecca Morgan, Cathy Merry*, Oksana Kehoe,
*University of Nottingham

Funded by EPSRC/MRC Centre for Doctoral Training in Regenerative Medicine

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Agents for Rheumatoid Arthritis

Mairead Hyland, Claire Mennan, Karina Wright, Roshan Amarasena*, Emma Wilson#, Aled Clayton*#, Oksana Kehoe
* RJAH Orthopaedic Hospital NHS Foundation Trust; #University of Chester; *#Cardiff University

Funded by the Orthopaedic Institute