ORTHOPAEDIC
INSTITUTE RESEARCH

Cell Therapies

CARTILAGE RESEARCH GROUP

Members of the Research Team: Karina Wright, Claire Mennan, Jan Herman Kuiper, Helen McCarthy, Charlotte Hulme, Sharon Owen,  Mike Williams,  Barbara Linklater-Jones, Naomi Dugard, Nikki Kuiper, Jade Perry, and PhD students, Abi Jones and Larissa Rix.

Clinical Support: Messrs Peter Gallacher, Paul Jermin, Professor Martyn Snow, Drs Bernhard Tins, Andrea Bailey, Professor Iain McCall and all surgeons in RJAH

Scientists based in the Leopold Muller Arthritis Research Centre and TORCH laboratories continue the long history of the RJAH Orthopaedic Hospital seeking to understand joint disorders and ways of treating them. The group has continued over the last 12 months focussing on particular areas such as chemical assays of ‘biomarkers’, growing cells in the laboratory and seeing how we can influence their behaviour and different aspects related to cell therapy. We are very fortunate in RJAH to be able to work closely with clinicians and surgeons who themselves are often very interested in research.  Much of the work involves analysing material from patients undergoing surgery which is being removed (eg an arthritic knee joint) and would otherwise be thrown in the bin. If patients are happy to allow us and the work is approved by a Research Ethics Committee, then we can put this ‘surgical waste’ to good use.  For example, biomarker studies can help unravel different chemical pathways involved in diseases and also to in see if sub-groups of patients can be identified who may suit a certain treatment more than others. The cell therapy work includes researching if we can produce ‘off-the-shelf’ cell products which could be much easier for the patient and surgeon to use, as well as being cheaper that growing patients’ own cells in the laboratory as happens now.

Most research is funded by grant applications, for example, from the Medical Research council or charities such as Versus Arthritis. We are however very grateful to the Orthopaedic Institute as the large grant-giving bodies usually require preliminary data, and the projects that the Institute fund are wonderful for obtaining this and help to get the larger grants.

Cell Therapy Projects

DONATED CARTILAGE STEM CELLS FOR CARTILAGE DEFECT REPAIR – ALLOGENEIC CHONDROPROGENITOR THERAPY PHASE II TRIAL (ACT2)

Jade Perry, Duncan Carroll, Charlotte Hulme, Larissa Rix, Tian Lan, Sally Roberts, Martyn Snow and Karina Wright

Funded by the Medical Research Council

ADVANCING HUMAN SYNOVIAL JOINTS-ON-CHIPS

Karina Wright, Martin Knight (QMUL), Timothy Hopkins, Sally Roberts, Charlotte Hulme and Clare Thompson (QMUL).

Funded by the Orthopaedic Institute

AN INVESTIGATION INTO PATELLOFEMORAL PAIN: IMPROVING DIAGNOSTICS, PROGNOSTICS AND CELL-BASED THERAPIES

Larissa Rix, Martyn Snow, Jan Herman Kuiper, Andrew Barnett, Karina Wright

Funded by the Orthopaedic Institute

SPONTANEOUS HEALING OF ARTICULAR CARTILAGE (SHARC)

Helen McCarthy, John Garcia, Sally Roberts, Bernhard Tins, Paul Jermin, Peter Gallacher, Oksana Kehoe, Karina Wright, Caroline Stewart, Jan Herman Kuiper

Funded by Medical Research Council

PREDICTION OF CLINICAL OUTCOME FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION BY MAGNETIC RESONANCE IMAGING

Helen McCarthy, Iain McCall, Claire Mennan, Mike Williams, James Richardson and Sally Roberts

Funded by Versus Arthritis and the MRC

TRANSCRIPTOME ANALYSIS OF THE UMBILICAL CORD-MESENCHYMAL STROMAL CELLS’ THERAPEUTIC RESPONSE TO INFLAMMATION, WITH A VIEW TO BANKING THE MOST POTENT CELLS FOR ALLOGENEIC THERAPY

Claire Mennan, Helen McCarthy, Daniel Tonge & Sally Roberts

Funded by the Orthopaedic Institute and Versus Arthritis

YOUNG HUMAN CHONDROCYTE EXPANSION IN THE QUANTUM® HOLLOW-FIBRE BIOREACTOR

Charlotte Hulme, John Garcia, Claire Mennan, Sally Roberts, Robert Freeman, Nigel Kiely, Derfel Williams and Karina Wright

Funded by the Medical Research Council

USING GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS

Hollie Wilkinson, Helen McCarthy, Karina Wright, Jade Perry and Paul Cool

Funded by the Orthopaedic Institute

HUMAN UMBILICAL CORD MESENCHYMAL STROMAL CELLS AS AN INJECTABLE FOR OSTEOARTHRITIS

Claire Mennan, Jade Perry, Karina Wright, Charlotte Hulme, Jamie McDonald, Emma Rand (York), Paul Genever (York), Karin Newall (Cambridge), Fran Henson (Cambridge) Martyn Snow, and Sally Roberts

Funded by the Orthopaedic Institute

AN EVALUATION OF THE SAFETY AND EFFICACY OF AUTOLOGOUS STEM CELLS, CHONDROCYTES OR THE TWO (ASCOT) FOR TREATING KNEE CARTILAGE DEFECTS

Clinical Delivery and Analysis: The late Professor James Richardson, Peter Gallacher, Paul Jermin, Martyn Snow, Bernhard Tins, Paul Harrison, Barbara Linklater-Jones, Jo Wales, Naomi Dugard, Jan Herman Kuiper

Scientific Investigations: Karina Wright, Helen McCarthy, Claire Mennan, Charlotte Hulme, Jade Perry, John Garcia, Lauren Tierney, Abi Jones, Sally Roberts

Funded by the Orthopaedic Institute, Versus Arthritis and the Medical Research Council

CELL THERAPY FOR REPAIR OF CARTILAGE DEFECTS IN THE ANKLE – HOW DOES IT WORK AND WHO SHOULD WE TREAT?

Tian Lan, Karina Wright, Nilesh Makwana, Andrew Bing, Charlotte Hulme and Helen McCarthy

Funded by the Orthopaedic Institute

SCIENTIFIC ANALYSIS OF THE ASCOT CELL TRANSPLANT – FOCUS ON TRANSCRIPTOMICS AND PROTEOMICS

Abi Jones, Lauren Tierney, Helen McCarthy, Sally Roberts, Charlotte Hulme, Jan Herman Kuiper, Martyn Snow, Dan Tonge, Mandy Peffers (Liverpool University) and Karina Wright

Funded by Versus Arthritis and the Medical Research Council

STRATIFICATION OF ORTHOPAEDIC PATIENTS USING BIOMARKERS

Charlotte Hulme, Jamie McDonald, Claire Mennan, Larissa Rix, Jan Herman Kuiper, Martyn Snow, Pete Gallacher, Paul Jermin and Karina Wright

Funded by the Orthopaedic Institute, Versus Arthritis and the Medical Research Council

THE OSCELL DATABASE

Mike Williams and Karina Wright

Funded by the Orthopaedic Institute

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