Registered Charity No. 1044906 01691 404661

ORTHOPAEDIC
INSTITUTE RESEARCH

Cell Therapies

CARTILAGE RESEARCH GROUP

Members of the Research Team: Sally Roberts, Karina Wright, Claire Mennan, Jan Herman Kuiper, Helen McCarthy, Johanna Wales, Charlotte Hulme, Sharon Owen,  John Garcia, Mike Williams,  Barbara Linklater-Jones, Paul Harrison, Nikki Kuiper and PhD students, Jade Perry, Tim Hopkins, Jingsong Wang (Kobe), Jessica Sykes  and Angus Armstrong-Twigg (Cardiff).

Clinical Support: Messrs Peter Gallacher, Paul Jermin, Drs Bernhard Tins, Andrea Bailey, Professor Iain McCall and all surgeons in RJAH

Scientists based in the Leopold Muller Arthritis Research Centre and TORCH laboratories continue the long history of the RJAH Orthopaedic Hospital seeking to understand joint disorders and ways of treating them. The group has continued over the last 12 months focussing on particular areas such as chemical assays of ‘biomarkers’, growing cells in the laboratory and seeing how we can influence their behaviour and different aspects related to cell therapy. We are very fortunate in RJAH to be able to work closely with clinicians and surgeons who themselves are often very interested in research.  Much of the work involves analysing material from patients undergoing surgery which is being removed (eg an arthritic knee joint) and would otherwise be thrown in the bin. If patients are happy to allow us and the work is approved by a Research Ethics Committee, then we can put this ‘surgical waste’ to good use.  For example, biomarker studies can help unravel different chemical pathways involved in diseases and also to in see if sub-groups of patients can be identified who may suit a certain treatment more than others. The cell therapy work includes researching if we can produce ‘off-the-shelf’ cell products which could be much easier for the patient and surgeon to use, as well as being cheaper that growing patients’ own cells in the laboratory as happens now.

Most research is funded by grant applications, for example, from the Medical Research council or charities such as Versus Arthritis. We are however very grateful to the Orthopaedic Institute as the large grant-giving bodies usually require preliminary data, and the projects that the Institute fund are wonderful for obtaining this and help to get the larger grants.

Cell Therapy Projects

PREDICTION OF CLINICAL OUTCOME FOLLOWING AUTOLOGOUS CHONDROCYTE IMPLANTATION BY MAGNETIC RESONANCE IMAGING

Helen McCarthy, Iain McCall, Claire Mennan, Mike Williams, James Richardson and Sally Roberts

Funded by Versus Arthritis and the MRC

BIOMARKER DISCOVERY IN ORTHOPAEDICS: MATCHING PATIENTS TO THE BEST TREATMENT

Charlotte Hulme, Heidi Fuller, Sally Roberts, Peter Gallacher, Karina Wright

Funded by Versus Arthritis

TRANSCRIPTOME ANALYSIS OF THE UMBILICAL CORD-MESENCHYMAL STROMAL CELLS’ THERAPEUTIC RESPONSE TO INFLAMMATION, WITH A VIEW TO BANKING THE MOST POTENT CELLS FOR ALLOGENEIC THERAPY

Claire Mennan, Helen McCarthy, Daniel Tonge & Sally Roberts

Funded by the Orthopaedic Institute and Versus Arthritis

BIOLOGICAL, PHYSICAL AND PSYCHOSOCIAL FACTORS THAT AFFECT THE HEALTH OF THE HUMAN KNEE

Timothy Hopkins, Karina Wright, Sally Roberts, Nicola Kuiper, Jan Herman Kuiper.

Funded by the Orthopaedic Institute

CAN CELLS FROM UMBILICAL CORDS BE USED TO TREAT PATIENTS WITH OSTEOARTHRITIS? Two Preclinical Studies

Jade Perry, Claire Mennan, Helen McCarthy, George Bou-Gharios*, Rob Van’T Hof*, Peter Milner*, Cosimo De Bari#, Anke Roelofs#, Karina Wright, James Richardson & Sally Roberts.  *Liverpool University; #Aberdeen University

Funded by Keele University & Versus Arthritis

THE SUITABILITY OF PRE-OPERATIVE MAGNETIC RESONANCE IMAGING IN PREDICTING ACCURATE CARTILAGE DEFECT SIZES FOR TREATMENT WITH CELL THERAPY

Jade Perry, Helen S. McCarthy, Sally Roberts, Paul Jermin, Peter D. Gallacher, James B. Richardson, Michael Williams, Bernhard Tins.

Funded by Keele University and Versus Arthritis

CELL-BASED MENISCUS TISSUE ENGINEERING: COMPARING MENISCUS CELLS, CHONDROCYTES, BMSCS AND CO-CULTURES ON SYNTHETIC SCAFFOLDS

Jingsong Wang, Sally Roberts, Bernhard Tins, James Richardson, Karina Wright

Funded by the Orthopaedic Institute

SPONTANEOUS HEALING OF ARTICULAR CARTILAGE (SHARC)

John Garcia, Sally Roberts, Bernhard Tins, Paul Jermin, Peter Gallacher, Oksana Kehoe, Karina Wright, Caroline Stewart, Jan Herman Kuiper

Funded by Medical Research Council (MRC)

HUMAN CHONDROCYTES EXPANDED IN THE QUANTUM® HOLLOW-FIBRE BIOREACTOR SYSTEM FOR THE FIRST TIME

John Garcia, Charlotte Hulme, Claire Mennan, Sally Roberts and Karina Wright

Funded by Arthritis Research UK and MRC